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Chicken Biscuit Casserole – Creamy, Cheesy & Comforting

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A creamy, cheesy chicken casserole made with biscuit pieces that bubble up as they bake. A fast, easy, family-friendly comfort food recipe.

Ingredients

Scale
  • 23 cups cooked chicken, shredded or diced

  • 1 can (10.5 oz) cream of chicken soup

  • 1 cup sour cream or Greek yogurt

  • ½ cup milk

  • 1½ cups shredded cheddar cheese, divided

  • 1 can (16 oz) refrigerated biscuits, quartered

  • ½ tsp garlic powder

  • ½ tsp onion powder

  • Salt and pepper to taste

  • Optional: 1 cup frozen mixed vegetables

Instructions

  • Preheat oven to 350°F. Grease a 9×13-inch baking dish.

  • In a bowl, mix soup, sour cream, milk, seasonings, and 1 cup cheese.

  • Stir in chicken and biscuit pieces until coated.

  • Pour into baking dish and spread evenly. Top with remaining cheese.

  • Bake uncovered for 35–40 minutes until golden and bubbly.

  • Rest for 5–10 minutes before serving. Garnish as desired.

Notes

Add cooked bacon or veggies for variation. Store leftovers in the fridge up to 3 days.